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Gene therapy for sickle cell and thalassemia gets approval in the UK, a world first

Published Wed, 05 Mar 2025 02:08:04 GMT

LONDON (AP) — Britain’s medicines regulator has authorized the world’s first gene therapy treatment for sickle cell disease, in a move that could offer relief to thousands of people with the crippling disease in the U.K.In a statement on Thursday, the Medicines and Healthcare Regulatory Agency said it approved Casgevy, the first medicine licensed using the gene editing tool CRISPR, which won its makers a Nobel prize in 2020. The agency approved the treatment for patients with sickle cell disease and thalassemia who are 12 years old and over. Casgevy is made by Vertex Pharmaceuticals (Europe) Ltd. and CRISPR Therapeutics. To date, bone marrow transplants, extremely arduous procedures that come with very unpleasant side effects, have been the only long-lasting treatment. “The future of life-changing cures resides in CRISPR based (gene-editing) technology,” said Dr. Helen O’Neill of University College London. “The use of the word ‘cure’ in relation to sickle cell dise...

Las contraseñas más utilizadas en el mundo: asegúrate de que la tuya no esté en la lista

Published Wed, 05 Mar 2025 02:08:04 GMT

Si desea que sus correos electrónicos, “banca en línea”, etc, estén a salvo de los piratas informáticos, sería prudente hacer un esfuerzo en buscar una contraseña segura.NordPass, la herramienta de gestión de contraseñas del equipo detrás de NordVPN, se asoció con investigadores independientes para publicar su estudio de las 200 contraseñas más comunes utilizadas en 2023.De las 20 contraseñas más comunes del mundo, 17 se pueden descifrar en menos de un segundo, así que piénselo dos veces antes de decidir ingresar “123456” o la aún más creativa “contraseña” para proteger sus cuentas en línea.Las contraseñas más populares son algunas de las combinaciones más vagas, incluso cuando las amenazas a la ciberseguridad siguen aumentando: más de 53 millones de ciudadanos estadounidenses se vieron afectados en la primera mitad de 2022, según datos de la AAG.El estudio de NordPass mostró que el 86% de los ciberataques utilizan credenciales robadas, y las cuen...

South Africa recovers to set Australia 213 to win Cricket World Cup semifinal after Miller’s 101

Published Wed, 05 Mar 2025 02:08:04 GMT

KOLKATA, India (AP) — South Africa recovered from a bad start to set Australia a target of 213 to win their semifinal match at the Cricket World Cup on Thursday.David Miller struck 101 to help the South Africans rebound from a perilous position at 24-4 in the 12th over and post a respectable 212 all out with two balls remaining in the innings.Heinrich Klaasen scored 47 runs off 48 balls and put on 95 off 113 for the fifth wicket with Miller to rescue the Proteas.The recovery came after Mitchell Starc and Josh Hazlewood took advantage of helpful overhead conditions to rip through the top order, leaving the South Africans struggling after winning the toss and choosing to bat first.Temba Bavuma (0) fell in the first over and a frustrated Quinton De Kock was out for just 3 off 14 balls when he skied Hazlewood to a backpedaling Pat Cummins.Aiden Markram got a thick outside edge off Starc to David Warner for 10 and Rassie van der Dussen (6) edged Hazlewood to Steve Smith at second slip.Th...

Xi-Biden meeting seen as putting rocky relations back on course, though main differences remain

Published Wed, 05 Mar 2025 02:08:04 GMT

TAIPEI, Taiwan (AP) — Perhaps just shaking hands and sitting down together can be enough sometimes. At their four-hour meeting Wednesday, U.S. President Joe Biden and his Chinese counterpart Xi Jinping didn’t resolve any of the vital geopolitical issues dividing the world’s two largest economies and chief rivals for global influence, but they struck a conciliatory tone that came as a relief to other countries, especially China’s neighbors. The two leaders met at a northern California country estate, holding talks, lunching and taking a garden stroll designed to show that while the two countries are global competitors, they’re not locked in a winner-take-all faceoff.“Planet Earth is big enough for the two countries to succeed,” Xi told Biden.Biden emphasized the need to avoid miscommunication. “We have to ensure competition does not veer into conflict,” he said. The leaders’ first face-to-face encounter in a year appears to have put a floor under a relat...

Última hora de Massa, Milei y las elecciones en Argentina 2023 en vivo

Published Wed, 05 Mar 2025 02:08:04 GMT

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These places need volunteers for Thanksgiving in Denver

Published Wed, 05 Mar 2025 02:08:04 GMT

DENVER (KDVR) — Thanksgiving is one week away, and it's time to start making plans for the holiday. Whether you're keeping it simple for the holiday, have some time off work or just want to give back, Denver has plenty of places to volunteer and donate. This is how much your Thanksgiving meal will cost this year FOX31 put together a list of places to volunteer or donate in Denver for the holiday. There are plenty of places to donate or volunteer in Denver, these are listed because they are advertised as Thanksgiving-related opportunities to provide families with food and other necessities during the holiday.Donate in Denver for ThanksgivingIf you don't have time to volunteer, you can always donate. These places are looking for monetary or food donations. While these spots promote Thanksgiving donations, they all take donations past the holiday.Ms. Betty's Harvest Madsgiving Dorinda Levy Thanksgiving Fund Denver Rescue Mission Denver Feed-A-Family 2023: In Honor of Daddy Bruce Rand...

Pentatonix spreads holiday cheer with new album and Christmas tour

Published Wed, 05 Mar 2025 02:08:04 GMT

Grammy-winning vocal group Pentatonix just wrapped their world tour and they’re already prepping for another one! They’re amping up holiday cheer with their new holiday album “The Greatest Christmas Hits” and a new holiday tour! The Grammy-winning A Cappella group Pentatonix is ready to kick off the holiday cheer with “The Most Wonderful Time of the Year Tour”.Mitch Grassi: “Christmas is always the best part of, of what we do because it’s, it’s the most fun, it’s the most festive, it’s the most showy tour that we do and, uh, we have a lot of really fun surprises in store for this Christmas show.”The group plans to outdo last year’s Christmas arena tour.Kristin Maldonado: “We’re adding in extra gags and things for the audience. New fun things for us. Doing a lot of new songs. I feel like now that we’ve done so many Christmas songs too, like, you’re really getting, like, all the hits,...

Travis Kelce sings on brother’s Christmas song

Published Wed, 05 Mar 2025 02:08:04 GMT

(CNN) — Taylor Swift might literally be able to make sweet music with Travis Kelce.The Kansas City Chiefs tight end has crossed over NFL lines to record a duet with his brother, Philadelphia Eagles center Jason Kelce.The pair teamed up for the song “Fairytale Of Philadelphia” from “A Philly Special Christmas Special.”According to the Philadelphia Inquirer, the project is “a Philly-ized rewrite of ‘Fairytale of New York,’ the Pogues’ 1987 tale of an Irish immigrant spending Christmas eve sleeping off a bender in the drink tank.”Travis Kelce’s higher register has been noted as a nice compliment to his brother Jason’s gruffer and lower voice on the song.The newspaper reported it was recorded before Travis Kelce was known to apparently be dating Swift.Neither Swift nor Kelce have verbally confirmed their relationship, choosing instead to let their lyrics, public displays of affection and togetherness speak for them.The Instagram account for the special posted a claymation-like...

South Florida deals with damage, flooding as communities brace for ongoing rain rounds

Published Wed, 05 Mar 2025 02:08:04 GMT

MIAMI-DADE/BROWARD COUNTIES, Fla. (WSVN) — South Florida faced a relentless storm, unleashing heavy rain, thunderstorms, and whipping winds throughout Wednesday. The aftermath reveals a region grappling with the impact of widespread flooding and record-breaking gusts. The widespread flooding has left many cars stranded across Miami-Dade County and Broward County. The aftermath of Wednesday’s heavy rainfall has resulted in road closures and has led Broward County Public Schools and Broward College to cancel classes on Thursday.A sinkhole opened at the intersection of Northwest 186th Street and 68th Avenue, leaving two cars submerged. Officials have not yet determined what led to the sinkhole, but the rain could be a factor.Another disaster occurred for a family in Miami when an abandoned two-story building collapsed due to unfavorable conditions, Wednesday. A family is now displaced as a result of that incident. Miami Beach experienced gusts reaching 74 miles per hour, ...

Finland slams shut some Russia border crossings

Published Wed, 05 Mar 2025 02:08:04 GMT

Finland announced Thursday it was completely closing four border crossings with Russia, shortly after accusing Moscow of pushing undocumented migrants toward the frontier.“We have acted decisively and swiftly to ensure that the situation on the eastern border does not worsen,” Prime Minister Petteri Orpo said, according to the Finnish news outlet Iltalehti. “Amendments were made to the Border Guard Act during the last parliamentary term specifically for such situations. Now these tools have been used.”Finnish Interior Minister Mari Rantanen said later at a press conference that “the risk of the situation escalating poses a serious threat to public order and national security,” adding that the closures — which begin Friday night — will be enforced until February 18, 2024.Finland’s move comes amid an increasing number of asylum-seekers crossing the border from Russia in recent weeks. Some other border crossings will remain open.“The gove...